A great number of doctors and scientists had tried to discover the nature of the microorganism responsible for the disease and had encountered great difficulty in isolating the bacillus. According to Budd, every case was related to another anterior case. William Budd, a doctor in Bristol who was interested in cholera and in intestinal fevers, demonstrated in 1873, that typhoid fever could be transmitted by a specific toxin present in excrement and that the contamination of water by the feces of patients was responsible for that propagation. He also tried, with his colleagues, to demonstrate that the spread of epidemic was related to drinking water contaminated by the excrement of patients with typhoid fever. Long before the bacillus responsible for the disease was discovered in 1880, Karl Liebermeister had already assumed that the condition was due to a microorganism.
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